A biosensor based upon a vertically emitting, distributed feedback (DFB) laser. The DFB laser comprises a replica-molded, one- or two-dimensional dielectric...
A biosensor based upon a vertically emitting, distributed feedback (DFB) laser. The DFB laser comprises a replica-molded, one- or two-dimensional dielectric grating coated with a laser dye-doped-polymer as the gain medium. A sensor is also described in which the grating layer and the active layer are combined into a single layer. DFB lasers using an inorganic or organic thin film with alternating regions of high and low index of refraction as the active layer are also disclosed. The sensor actively generates its own narrowband high intensity light output without stringent requirements for coupling alignment, thereby resulting in a simple, robust illumination and detection configuration.
Dr. Galvez from the University of Illinois explores a promising direction for understanding the underlying mechanisms behind Fragile X Syndrome-related...
Dr. Galvez from the University of Illinois explores a promising direction for understanding the underlying mechanisms behind Fragile X Syndrome-related abnormalities. By analyzing endothelial vasculature growth and its association with Fragile X Syndrome (FX), Dr. Galvez has effectively alleviated both physical and cognitive abnormalities related to FX, in FX-afflicted mice.
There is currently no cure for Fragile X. The Galvez lab's research has the potential to treat the syndrome itself instead of treating the associated effects of the syndrome such as attention deficit and social anxiety.
Dr. Freund is developing a method of treating anxiety with the diabetes drug, glyburide. By exploring the effects of anxiogenics like adenosine on the brain, Dr....
Dr. Freund is developing a method of treating anxiety with the diabetes drug, glyburide. By exploring the effects of anxiogenics like adenosine on the brain, Dr. Freund is developing the treatment of anxiety through use of ATP-sensivitive potassium channel blockers. Though there are many anxiety medications currently available, these drugs have various side effects. Additionally, current medications are not effective on all individuals, but the number of people using anti-anxiety medication is increasing.
Dr. Brenda Wilson has developed an anti-toxin that can be used for treatment of botulism. The botulinum toxin causes dangerous paralysis of motor neurons that can...
Dr. Brenda Wilson has developed an anti-toxin that can be used for treatment of botulism. The botulinum toxin causes dangerous paralysis of motor neurons that can lead to breathing complications. Existing anti-toxin therapy only works on toxins circulating in the bloodstream and not on cells that are already intoxicated with botulinum toxin. Dr. Wilson's invention can specifically treat botulinum-intoxicated neurons and can neutralize the toxin intracellularly. In vivo experiments in a mouse model have shown treatment with the anti-toxin can reverse botulism paralysis. This invention has the potential to speed recovery for individuals suffering from the devastating effects of botulism intoxication.
Below the knee muscle weakness, defined by weak dorsiflexor (shin) or plantarflexor (calf) muscle groups, can result from a variety of physical impairments or...
Below the knee muscle weakness, defined by weak dorsiflexor (shin) or plantarflexor (calf) muscle groups, can result from a variety of physical impairments or congenital abnormalities. Stroke, spinal cord injuries, polio and multiple sclerosis are among some of the physical injuries and congenital defects responsible for the condition. The largest complication from below the knee muscle weakness is abnormal gait, which when compensated for can lead to further complications in other muscles and joints.
Ankle-foot-orthoses (AFOs) have been designed to assist afflicted individuals in walking and rehabilitation of the weakened muscle groups. Unfortunately, many commercially available AFOs are passive devices that cannot provide assistance during the propulsive phase of gait. Furthermore, these instruments are not capable of adapting to changes in walking conditions. Powered AFOs have been engineered to overcome these limitations but lack practicality in that they are commonly tethered to off-board power sources.
This technology provides a non-tethered, portable pneumatic powered AFO that controls and assists propulsion of the foot as well as ankle motion using plantarflexor and dorsiflexor torque at the ankle joint.
A custom-built pneumatic rotary actuator is located at the ankle joint. Torque generated by the actuator is used for both motion control of the foot and to provide supplemental torque for the individual during gait. Pressure regulators are used to manage the force produced by the rotary actuator and valves are used to direct the flow of fluid power to the actuator. Control and sensing of the actuator is accomplished through use of pressure and angle sensors and onboard electronics.
This device can be used to aid individuals afflicted with below the knee muscle weakness or impaired gait resulting from any number of physical injuries or congenital disabilities. Portability of the device permits the device to be used in a variety of locations. Applications include:
The portable pneumatic AFO is beneficial compared to passive AFOs in that it:
Benefits over other powered AFOs include: