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Although there are already a few existing compounds for use in the treatment of bone diseases, these new compounds may have efficacy exceeding that of current...
Although there are already a few existing compounds for use in the treatment of bone diseases, these new compounds may have efficacy exceeding that of current commercial species. In some cases, existing treatments have high toxicity and low efficacy. These new compounds may, therefore, be better than existing therapeutic options.
These new compounds can help restore the natural balance between normal bone destruction and replacement. They are also potential candidates for the treatment of cancer and infectious diseases as related compounds have been shown to kill tumor cells and parasites. They have been shown to stimulate T-Cells, assisting in the treatment of cancer and infectious diseases.
They have multiple targets, some involved in regulating apoptosis, and displays increased potency, making it a possible cancer drug. Its improved cell availability lowers the effective dose and can lead to fewer side effects.
These compounds make up a series of bisphosphonates useful for the treatment of bone-related diseases, cancer and infections caused by protozoa and bacteria. The compounds represent new compositions of matter. Current clinical Bisphosphonates contain a nitrogen atom that can be positively charged. The new compounds have positively charged P, As, Sb, S, Se or Te sites instead of nitrogen. They may have higher activity in treating a variety of diseases than existing compounds and may have lower toxicity than existing compounds.
A near-field microscope using one or more diffractive elements placed in the near-field of an object to be imaged. A diffractive covers the entire object, thus...
A near-field microscope using one or more diffractive elements placed in the near-field of an object to be imaged. A diffractive covers the entire object, thus signal may thereby be gathered from the entire object, and advantageously increase the signal-to-noise ratio of the resulting image, as well as greatly improve the acquisition speed. Near-field microscopy overcomes the limitation of conventional microscopy in that subwavelength and nanometer-scale features can be imaged and measured without contact.
This technology is a short fragment of a naturally occurring peptide that can be used to regulate the density of calcium current in mammalian cells. Modulation of...
This technology is a short fragment of a naturally occurring peptide that can be used to regulate the density of calcium current in mammalian cells. Modulation of calcium current across cell membranes is an essential step in muscle contraction, neuronal signaling, and hormone release.
Voltage dependent channels are multimetric proteins that reside within the surface membranes of cells. The activation of these channels allows for a wide range of cellular functions to take place, such as the release of neurotransmitters, muscle contraction, and the transmission of pain signals. Any chemical agent that alters calcium channel function has the ability to modify these, and many other, cellular processes. Calcium Channels are already targets of therapeutic agents and regulatory therapies for individuals who struggle with various symptoms related to restricted blood-flow, as well as therapies aimed at pain pathways. Calcium channel blockers (CCBs), for instance, behave like cork stoppers in a bottle, preventing any calcium ions from passing through the plugged channel.
This affect can decrease workload on a stressed heart and prevent it from operating anaerobically and can regulate the contractility of vascular smooth muscle to decrease blood pressure.
This calcium channel inhibitor is based on a naturally occurring peptide that is known to regulate calcium current density. By mimicking the action of the identified 6 subunit, this synthetic, lipophillic peptide alters the density of calcium current by decreasing the number of active channels in the cell.
Expression of this peptide fragment within the cell reduces the normal calcium current by 30% ~ 50%, which can greatly alter the cell function. This peptide is a strong candidate for further pharmaceutical research and drug design.
This calcium current inhibitor represents a mechanistically novel, potentially safer, method of regulating calcium current density by altering the number of active calcium channels in the membrane rather than interfering with the movement of calcium through channels as is the case with the calcium channel blockers (CCBs).
This fuel cell is an invention of miniature proportions. University of Illinois researchers have developed the ability to integrate alkaline and mixed-media...
This fuel cell is an invention of miniature proportions. University of Illinois researchers have developed the ability to integrate alkaline and mixed-media electrochemistries into microfluidic fuel cells. This technology takes advantage of two well documented phenomena: 1. the high output of alkaline electrochemical reactions; and 2. the reliable, low-maintenance qualities of laminar flow. Microfluidic alkaline fuel cells eliminate the need for a semi-permeable membrane (PEM) and operate under the unique principles of laminar flow in which substances interact without experiencing turbulent mixing.
The development of alkaline chemistries using microfluidics advances micro-fuel cell technology closer to practical application. By designing a microfluidic fuel cell that can accept a variety of electricity-generating fuels, this development enhances the range of possibilities for the future of fuel cell technology. Of the different types of fuel cell systems, the polymer electrolyte membrane fuel cell (PEM-FC) has been recognized as one of the most promising candidates to overcome the challenges of miniaturization.
Hydrogen is one of the primary fuels used in PEM-FCs; but in order to obtain micro-PEM-FCs with practical energy densities, the lightweight, extremely flammable gas must be stored at high pressure, which requires extreme safety measures and large energy investments. Safer high energy-density fuels, such as methanol and formic acid, have been the focus of intense research as well, but they present their own unique obstacles. Micro-scale fuel cells using a microfluidic architecture operate under a different principle than micro-scale PEM-based fuel cells.
Rather than keep the reagents separated with a semi-permeable membrane, a unique Y-shaped microfabrication method allows the two chemicals to flow laminarly in parallel without experiencing turbulent mixing. This phenomenon permits a free exchange of hydroxide ions at the liquid-liquid interface without concern for the stability of a semi-permeable membrane. Alkaline reactions convert the highly energy-dense hydrocarbon methanol and oxygenated liquid into the harmless byproducts of carbon dioxide and water; microfluidic fuel cell arrays can then be arranged to handle varying wattage requirements.
Advances in microelectronics and wireless technology have lead to a relentless demand for efficient and reliable power sources to fuel productivity. As much as half of the weight of many contemporary electronic devices can be attributed to the battery. Fuel cells have been tapped as an alternative because of their high energy density, or energy to weight ratio.
Portable electronics: As the size of electronic equipment, such as cell phones, GPS systems and laptop computers, continues to shrink, industry demand increases for equally smaller power supplies. Customizable, high-power microfluidic fuel cells offer the potential to provide lighter, smaller solutions for such devices.
Batteries common to the average household operate in alkaline chemistries because of the reaction's high electrical output and relatively low materials cost. The development of alkaline-based microfluidic fuel cells transfers that desirable combination to the cutting-edge of fuel cell technology.
This technology describes a fabrication method for multi-channel, multi-layered microfluidic devices, with numerous functional characteristics capable of...
This technology describes a fabrication method for multi-channel, multi-layered microfluidic devices, with numerous functional characteristics capable of integration into a lab-on-a-chip platform. The chip allows broader analytical capabilities in point-of-use microfluidic technology than previously possible, and it does so with exceeding strength and stability.
Fabrication of this chip is made possible by a transfer process of labile membranes and the development of a contact printing method for a thermally curable epoxy-based adhesive. This adhesive has bond strengths that prevent leakage, channel rupture and delamination to nearly 6atm. Channels on the chip - 100 m wide and 20 m deep - are contact printed without the adhesive entering the microchannel.
The chip is characterized in terms of resistivity measurements along the microfluidic channels, electroosmotic flow (EOF) measurements at differing pH levels and laser-induced-fluorescence (LIF) detection of green-fluorescent (GFP) plugs injected across the nanocapillary membrane and into a microfluidic channel. The resulting product is a mixed-polymer micro-nanofluidic multilayer chip, which has the electrical characteristics necessary for use in microanalytical systems.
About our Portfolio
The University of Illinois at Urbana-Champaign is a world-class research institution boasting a respected and accomplished faculty, high national rankings, state-of-the-art facilities, and a history of ground-breaking research. The University's research budget is more than $600 million annually, placing it among the nation's top generators of innovation.
The Office of Technology Management's portfolio of licensable innovations represents the breadth and depth of the University's research enterprise.
Ready-to-Sign Licensing Program
The goal of this program is to facilitate rapid licensing and the transfer of University intellectual property. Standard terms and conditions have already been determined for each of these technologies, as represented in the linked agreements which are are "ready-to-sign." The terms reflected in Ready-to-Sign agreements are only available to qualified parties who complete the required information, sign, and return the agreement without modification to the Office of Technology Management.
Encouraging Economic Development in Illinois
If you will be developing or producing Products that are covered by the RtS License in the state of Illinois, we will waive the 1st year fee. To qualify for this waiver, on Part 1 of the License indicate the Illinois address where you will be developing or making Products covered by the RtS License.